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Proteasome impairment in neural cells
Paper format (Toxicology)
A literature review has four main objectives:
Cells: Mouse Neural cells (e.g., N2a neuroblastoma/ Rat C6 Glioma cell line)
Compounds: AAPH (lipid peroxidation), H2O2 (oxidative stress), Rotenone (mitochondrial inhibitor), MG132 (proteasome inhibitor), Antioxidants (NAC, Sulforaphane, Vit E).
Techniques: Tissue Culture, Viability Assessment (MTT reduction assay, Cell-Titre Blue, Trypan Blue,), Proteasome activity assays, Reactive oxygen species assay, Antioxidant levels.
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